The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity

The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity

Blog Article

NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers, including aggressive pancreatic tumors.Recent studies have indicated a role for NDRG1 in the inhibition of multiple tyrosine kinases, including EGFR, c-Met, HER2 and HER3, etc.The mechanism of activity of NDRG1 remains unclear, g5210t-p90 but to impart some of its functions, NDRG1 binds directly to key effector molecules that play roles in tumor suppression, e.

g., MIG6.More recent studies indicate that NDRG1s-inducing drugs, such as novel di-2-pyridylketone thiosemicarbazones, not only inhibit tumor growth and metastasis but also fibrous here desmoplasia, which leads to chemotherapeutic resistance.

The Casitas B-lineage lymphoma (c-Cbl) protein may be regulated by NDRG1, and is a crucial E3 ligase that regulates various protein tyrosine and receptor tyrosine kinases, primarily via ubiquitination.The c-Cbl protein can act as a tumor suppressor by promoting the degradation of receptor tyrosine kinases.In contrast, c-Cbl can also promote tumor development by acting as a docking protein to mediate the oncogenic c-Met/Crk/JNK and PI3K/AKT pathways.

This review hypothesizes that NDRG1 could inhibit the oncogenic function of c-Cbl, which may be another mechanism of its tumor-suppressive effects.